7-Ketocholesterol

SKU: orb1297026

Description

7-Ketocholesterol is an oxysterol metabolite of cholesterol, widely used in research on oxidative stress, atherosclerosis, and cell death (e.g., oxiapoptophagy). It serves as a key biomarker and experimental tool for studying lipid peroxidation and its roles in various in vitro and in vivo disease models.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 566-28-9
• MW: 400.65
• Purity: 98.84%
• Formula: C₂₇H₄₄O₂
• SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CC[C@H](O)CC1=CC3=O
• Target: Endogenous Metabolite,Others,p38 MAPK
• Solubility: DMSO:< 4.01 mg/mL (10 mM)

Bioactivity

• In Vivo:
  7-ketocholesterol (7KC), in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation. 7KC induces a dose-dependent loss of cell viability and an increase in apoptosis and necrosis in the endothelial cells. A relocalization of the tight junction proteins, zonula occludens-1 (ZO-1) and claudin-5, towards the nucleus of the cells was also observed. These effects were significantly attenuated by ET. In addition, 7KC induces marked increases in the mRNA expression of pro-inflammatory cytokines, IL-1β IL-6, IL-8, TNF-α and cyclooxygenase-2 (COX2), as well as COX2 enzymatic activity, and these were significantly reduced by ET.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

orphan disease, inhibit, Inhibitor, Endogenous Metabolite, HMG-CoA reductase, 7 Ketocholesterol, 7Ketocholesterol, 7-Ketocholesterol, coronary artery disease, cholesterol biosynthesis

Compound Identifiers

PubChem CID

91474