653-47 hydrochloride

SKU: orb1298548

Description

653-47 hydrochloride is a compound that enhances the inhibitory effect of 666-15 on CREB. While it exhibits weak direct CREB inhibition itself (IC50 = 26.3 µM), its primary role is as a potentiator. This makes it a useful research tool for studying CREB-driven pathways in cancer and other diseases in cellular models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1224567-46-7
• MW: 407.29
• Purity: 99.65% (May vary between batches)
• Formula: C₂₀H₂₀Cl₂N₂O₃
• SMILES: Cl.NCCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O
• Target: Epigenetic Reader Domain
• Solubility: DMSO:250 mg/mL (613.81 mM);10% DMSO+90% Saline:3.3 mg/mL (8.1 mM)

Bioactivity

• Target IC50:
  CREB:26.3 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

potentiate, transcription, 653 47 hydrochloride, 653-47, 65347 hydrochloride, 653-47 Hydrochloride, cancers, CREB, Epigenetic Reader Domain, EpigeneticReaderDomain, factor, inhibit, Inhibitor

Compound Identifiers

PubChem CID

46187341