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653-47 hydrochloride

SKU: orb1219017

Description

653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.

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Key Properties

CAS Number1224567-46-7
MW407.29
Purity>98% (HPLC)
FormulaC20H20Cl2N2O3
SMILESO=C(NC1=CC=C(C=C1O)Cl)C2=C(C=C3C=CC=CC3=C2)OCCCN.Cl
TargetEpigenetic Reader Domain
SolubilityDMSO:250 mg/mL (613.81 mM; Need ultrasonic)

Bioactivity

In Vitro
653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • 653-47 hydrochloride [orb1298548]

    99.65% (May vary between batches)

    1224567-46-7

    407.29

    C20H20Cl2N2O3

    5 mg, 10 mg, 25 mg, 100 mg, 500 mg, 50 mg, 1 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

653-47 hydrochloride (orb1219017)

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Available Sizes

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5 mg
$ 280.00
10 mg
$ 510.00
25 mg
$ 830.00
50 mg
$ 1,170.00
100 mg
$ 1,590.00
500 mg
$ 3,150.00