5A2-SC8

SKU: orb1982929

Description

5A2-SC8 is a cationic lipid designed for nucleic acid delivery, facilitating the transport of small RNA therapeutics into cells via electrostatic interactions with anionic membranes. Its utility is demonstrated in both in vitro transfection studies and in vivo models for gene therapy and drug delivery applications.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1857341-90-2
• MW: 1841.71
• Formula: C₉₃H₁₇₃N₅O₂₀S₅
• SMILES: O=C(OCCOC(=O)C(C)CSCCCCCCCC)CCN(CCNCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCNCCN(CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC)CCC(=O)OCCOC(=O)C(C)CSCCCCCCCC
• Target: Liposome
• Solubility: DMSO:80 mg/mL (43.44 mM)

Bioactivity

• In Vivo:
  A single dose of 75 mg/kg 5A2-SC8 administered intravenously was well tolerated in chronically ill mice with invasive hepatocellular carcinoma and did not adversely affect survival. Intravenous injection of 0.5 mg/kg 5A2-SC8 was effective in crossing the first barrier of hepatic Kupffer cells and was internalized by hepatocytes after 6 hours in the presence of siFVII labeled with Cy5.5 dye.
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• In Vitro:
  5A2-SC8 is taken up by hepatocytes by binding to the LDL receptor (LDL-R) on the surface of hepatocytes and undergoing receptor-mediated endocytosis with the aid of a crown of surface-adsorbed ApoE protein.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Liposome

Compound Identifiers

PubChem CID

129092701