5α-Pregnane-3β,6α-diol-20-one

SKU: orb1308876

Description

5α-Pregnane-3β,6α-diol-20-one is a mitogenic progesterone metabolite synthesized by androgen-responsive prostate cancer cells under nutrient deprivation. It is utilized in research to study intracrine steroidogenesis, tumor cell survival mechanisms, and proliferation pathways in both in vitro and in vivo cancer models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 21853-11-2
• MW: 334.49
• Purity: 99.95% (May vary between batches)
• Formula: C₂₁H₃₄O₃
• SMILES: [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](O)[C@@]2([H])C[C@@H](O)CC[C@]12C
• Target: Drug Metabolite,Others
• Solubility: DMSO:100 mg/mL (298.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.96 mM)

Bioactivity

• In Vitro:
  Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts . Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather dependent on 3β-HSD activity .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, 5αPregnane3β,6αdiol20one, 5α-Pregnane-3β,6α-diol-20-one, 5α Pregnane 3β,6α diol 20 one, 5alpha-Pregnane-3beta,6alpha-diol-20-one, 5a-Pregnane-3b,6a-diol-20-one

Compound Identifiers

PubChem CID

11035016