5α-Pregnane-3β,6α-diol-20-one

SKU: orb1218431

Description

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone. It can be produced in starved androgen-responsive prostate cancer cells.

Key Properties

• CAS Number: 21853-11-2
• MW: 334.49
• Purity: >98% (HPLC)
• Formula: C₂₁H₃₄O₃
• SMILES: C[C@@]12[C@]3([H])[C@](C[C@H](O)[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)([C@@H](C(C)=O)CC4)CC3
• Target: Others
• Solubility: DMSO:100 mg/mL (298.96 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  Progesterone is converted to 5α-pregnane-3β, 6α-diol-20-one in human fibroblasts. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β, 6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β, 6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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