5-HT4 antagonist 1

SKU: orb1310042

Description

This compound is a potent and selective 5-HT4 receptor antagonist, exhibiting a pKi value of 9.6. It is a valuable research tool for investigating serotonin signaling in both in vitro binding assays and in vivo models of gastrointestinal and central nervous system function.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 261766-73-8
• MW: 480.62
• Purity: 99.86% (May vary between batches)
• Formula: C₂₃H₃₆N₄O₅S
• SMILES: CN1CCN(CC1)S(=O)(=O)CCCN1CCC(CNC(=O)c2cccc3OCCOc23)CC1
• Target: 5-HT Receptor
• Solubility: DMSO:3.67 mg/mL (7.64 mM)

Bioactivity

• Target IC50:
  5-HT4 receptor:9.6 (pki)
• In Vivo:
  5-HT4 antagonist 1 demonstrates good exposure and prolongs t1/2 in other species with t1/2 of 7, 12, and 21 hours for mice, rats, and mini-pig.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-hydroxytryptamine Receptor, 5HTReceptor, 5-HT4 Receptor, 5HT4 antagonist 1, 5-HT4 antagonist 1, 5-HT-4 antagonist 1, 5-HT4, 5 HT4 antagonist 1, 5-HT Receptor, 5HT Receptor, Inhibitor, inhibit, Serotonin Receptor

Compound Identifiers

PubChem CID

9869791