Sulamserod

SKU: orb1708453

Description

Sulamserod (RS 100302) is a potent and selective 5-HT4 receptor antagonist utilized in cardiovascular research. Its antiarrhythmic properties are investigated in both in vitro assays and in vivo animal models for the study of atrial fibrillation mechanisms and potential therapeutic interventions.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 219757-90-1
• MW: 445.96
• Purity: 98.76% (May vary between batches)
• Formula: C₁₉H₂₈ClN₃O₅S
• SMILES: O=C(C1=CC(Cl)=C(N)C=2OCCOC21)CCC3CCN(CCNS(=O)(=O)C)CC3
• Target: 5-HT Receptor

Bioactivity

• In Vivo:
  In pigs, the administration of Sulamserod at a dose of 30 mg/kg results in significant effects on electrophysiological parameters. Specifically, Sulamserod prolongs the mean effective refractory period (ERP) (14667 ms versus 11568 ms, P < 0.01) and wavelength (9.960.8 cm versus 8.360.9 cm, P < 0.01). Additionally, it reduces the dispersion of ERP (861 ms versus 1565 ms, P < 0.01) and causes a minimal slowing of conduction velocity (6765 cm/s versus 7264 cm/s, P < 0.01). Notably, Sulamserod does not induce any ventricular electrophysiological effects. Moreover, its administration leads to the termination of atrial flutter in 6 out of 8 animals and atrial fibrillation in 8 out of 9 animals. Furthermore, Sulamserod effectively prevents the reinduction of sustained tachycardia in all animals.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HTReceptor, 5HT Receptor, 5-HT4 Receptor, 5-HT4, RS 100302, RS100302, RS-100302, Sulamserod

Compound Identifiers

PubChem CID

9805252