5-HT3 antagonist 5

SKU: orb1685205

Description

This quinoxalin-2-carboxamide derivative is a potent and selective 5-HT3 receptor antagonist, blocking agonists like 2-methyl-5-HT. It has demonstrated antidepressant-like activity in murine models, supporting its use in neuroscience research for studying serotonin signaling and mood disorders.

Research Area

Neuroscience, Neuroscience; Pharmacology & Drug Discovery, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 901599-43-7
• MW: 279.29
• Purity: 99.84% (May vary between batches)
• Formula: C₁₆H₁₃N₃O₂
• SMILES: COc1ccc(NC(=O)c2cnc3ccccc3n2)cc1
• Target: Others,5-HT Receptor

Bioactivity

• In Vivo:
  Compound 4c, a 5-HT3 antagonist administered at 1 mg/kg intraperitoneally as a single dose, effectively reduced immobility duration, demonstrating an antidepressant effect in Forced Swim Test (FST) mice . This experiment utilized Swiss albino mice weighing 23 ± 2 g . Despite its significant effect on immobility, compound 4c did not alter the spontaneous locomotor activity in these animals, indicating its specificity in exhibiting the antidepressant effect without affecting general locomotion.
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• In Vitro:
  Compound 4c, a 5-HT3 antagonist, demonstrates effective antagonism against the 5-HT3 receptor in the longitudinal muscle myenteric plexus of the guinea pig ileum. This activity is observed when challenged with the 5-HT3 agonist, 2-methyl-5-HT, manifesting a pA2 value of 5 .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

WAY 327157, WAY327157, 5-HT3 antagonist 5

Compound Identifiers

PubChem CID

4416580