VUF 10166

SKU: orb1300520

Description

VUF10166 is a highly potent and selective competitive antagonist of the 5-HT3A receptor, exhibiting sub-nanomolar affinity (Ki = 0.04 nM) with significantly reduced activity at heteromeric 5-HT3AB receptors. This selectivity makes it a valuable research tool for in vitro and in vivo studies investigating the specific roles of 5-HT3A receptors in neurotransmission, emesis, and anxiety-related behaviors.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 155584-74-0
• MW: 262.74
• Purity: 99.66% (May vary between batches)
• Formula: C₁₃H₁₅ClN₄
• SMILES: CN1CCN(CC1)c1nc2ccccc2nc1Cl
• Target: 5-HT Receptor
• Solubility: DMSO:26.3 mg/mL (100.1 mM);Ethanol:26.3 mg/mL (100.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.61 mM)

Bioactivity

• Target IC50:
  5-HT3AB:22 nM (Ki)|5-HT3A:0.04 nM(Ki)
• In Vitro:
  VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-hydroxytryptamine Receptor, 5-HT3 receptor ligand, 5-HT3A, 5-HT3AB, 5HTReceptor, agonist, 5HT Receptor, 5-HT Receptor, inhibit, neurotransmission, Inhibitor, Serotonin Receptor, VUF10166, VUF-10166, VUF 10166

Compound Identifiers

PubChem CID

24278976