5-Aminolevulinic acid hydrochloride

SKU: orb1307847

Description

5-Aminolevulinic acid hydrochloride (5-ALA HCl) is a biochemical precursor in the biosynthesis of heme and all tetrapyrrole compounds. It is widely used in research, notably in photodynamic therapy studies and as a tool to induce protoporphyrin IX accumulation for both in vitro and in vivo investigations.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5451-09-2
• MW: 167.59
• Purity: 98.00% (May vary between batches)
• Formula: C₅H₁₀ClNO₃
• SMILES: Cl.NCC(=O)CCC(O)=O
• Target: Autophagy,Mitophagy,Apoptosis,Endogenous Metabolite
• Solubility: DMSO:138 mg/mL (823.44 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (23.87 mM);Ethanol:6 mg/mL (35.8 mM);H2O:31 mg/mL (184.98 mM)

Bioactivity

• In Vitro:
  5-Aminolevulinic acid (5-ALA), a non-fluorescent prodrug, facilitates the intracellular build-up of fluorescent porphyrins in malignant gliomas, aiding in their intraoperative identification and removal. A study with a median follow-up of 35.4 months (95% CI 1.0-56.7) showed that 65% (90 out of 139) of patients treated with 5-ALA achieved complete resection of contrast-enhancing tumors, compared to only 36% (47 out of 131) in those using white light, marking a significant difference of 29% (95% CI 17-40, p<0.0001). Additionally, those treated with 5-ALA exhibited a higher 6-month progression-free survival rate of 41.0% (32.8-49.2) versus 21.1% (14.0-28.2) for the white light group, a difference of 19.9% (9.1-30.7, p=0.0003, Z test). However, 5-ALA alone was deemed insufficient for achieving gross total resection without risking postoperative neurological damage. In treating functional grade III gliomas, the combination of intraoperative MRI (iMRI) with functional neuronavigation significantly outperformed the 5-ALA resection technique.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Autophagy, 5 Aminolevulinic acid hydrochloride, 5-Aminolevulinic acid, 5-Aminolevulinic acid HCl, 5Aminolevulinic acid hydrochloride, 5-Aminolevulinic acid Hydrochloride, 5-ALA, ALA Hydrochloride, ALA hydrochloride, Mitophagy, Mitochondrial Autophagy, inhibit, Endogenous Metabolite, EndogenousMetabolite, Inhibitor, Hydrangin, δ-Aminolevulinic acid

Compound Identifiers

PubChem CID

123608