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4EGI-1

SKU: orb1225325

Description

4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor with Kd of 25 uM (binding to eIF4E); disrupts eIF4E/eIF4G association and inhibits cap-dependent translation; inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activity against multiple cancer cell lines.

Images & Validation

Key Properties

CAS Number315706-13-9
MW451.2833
Purity>98% (HPLC)
FormulaC18H12Cl2N4O4S
SMILESO=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N/NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2
TargeteIF
SolubilityDMSO: ≥ 35 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

eIF4E/eIF4G Interaction Inhibitor

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Protocol Information

Available Sizes

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100 mg
200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 160.00
10 mg
$ 200.00
25 mg
$ 370.00
50 mg
$ 580.00