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(4-NH2)-Exatecan

SKU: orb1690795

Description

(4-NH2)-Exatecan is a potent topoisomerase I inhibitor designed for the development of antibody-drug conjugates (ADCs). It demonstrates significant antitumor activity in preclinical in vitro and in vivo models, making it a valuable payload for oncology research focused on targeted cancer therapies.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2495742-21-5
MW403.43
Purity99.89% (May vary between batches)
FormulaC23H21N3O4
SMILESCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(N)c5CCCc(c3Cn1c2=O)c45
TargetADC Cytotoxin,Topoisomerase
SolubilityDMSO:80 mg/mL (198.3 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ADCCytotoxin, ADC Cytotoxin, (4 NH2) Exatecan, (4NH2)Exatecan, (4-NH-2)-Exatecan, (4-NH2)-Exatecan, Topo

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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100 mg
1 mg
$ 120.00
5 mg
$ 220.00
1 ml x 10 mM (in DMSO)
$ 250.00