Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan

SKU: orb2279089

Description

Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is a cleavable linker-payload used in constructing antibody-drug conjugates (ADCs). It incorporates a topoisomerase I inhibitor derivative for targeted cytotoxicity, enabling research into ADC efficacy and mechanism in both in vitro and in vivo cancer models.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2495742-34-0
• MW: 1148.26
• Formula: C₅₇H₇₇N₇O₁₈
• SMILES: O=C1N2C(C=3C(=C4C=5C(N3)=CC=C(NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN6C(=O)C=CC6=O)=O)=O)C(C)C)=O)C)=O)C5CCC4)C2)=CC7=C1COC(=O)[C@@]7(CC)O
• Target: Drug-Linker Conjugates for ADC,Topoisomerase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155142254