4-IBP

SKU: orb1302724

Description

4-IBP is a potent and selective sigma-1 receptor agonist, exhibiting high affinity (Ki = 1.7 nM) for σ1R and moderate affinity for σ2R. It is a valuable research tool for investigating sigma receptor function in neuropharmacology, with applications in both in vitro binding assays and in vivo behavioral studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 155798-08-6
• MW: 420.29
• Purity: 99.12% (May vary between batches)
• Formula: C₁₉H₂₁IN₂O
• SMILES: Ic1ccc(cc1)C(=O)NC1CCN(Cc2ccccc2)CC1
• Target: Apoptosis,Autophagy,Sigma receptor
• Solubility: DMSO:7.86 mg/mL (18.7 mM);Ethanol:5 mM

Bioactivity

• Target IC50:
  σ2 receptor:25.2 nM|σ1 receptor:1.7 nM
• In Vivo:
  4-IBP increases the antitumor effects of temozolomide and irinotecan in immunodeficient mice that were orthotopically grafted with invasive cancer cells.
• In Vitro:
  4-IBP is a σ1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells. 4-IBP is used to investigate whether targeting theσ1 receptor could modify in vitro the migration rates of human cancer cells and increase the sensitivity of metastasizing human A549 NSCLC cells and infiltrating human glioblastoma cells to cytotoxic insults of either proapoptotic or proautophagic drugs.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, 4IBP, 4-IBP, 4 IBP, Sigmareceptor, Sigma receptor, Sigma Receptor, σ1, σ2

Compound Identifiers

PubChem CID

132995