360A

SKU: orb1220426

Description

360A is a stabilizing G-Quadruplex ligand and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).

Key Properties

• CAS Number: 794458-56-3
• MW: 449.5
• Purity: >98% (HPLC)
• Formula: C₂₇H₂₃N₅O₂
• SMILES: C[n+]1cc(NC(=O)c2cccc(n2)C(=O)Nc2c[n+](C)c3ccccc3c2)cc2ccccc12
• Target: Telomerase

Bioactivity

• In Vitro:
  360A inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Telomerase