3,4,5-Trimethoxy-trans-cinnamic acid

SKU: orb1218509

Description

3,4,5-Trimethoxy-trans-cinnamic acid is a natural product from the roots and rhizomes of Notopterygium incisum.

Key Properties

• CAS Number: 20329-98-0
• MW: 238.24
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₄O₅
• SMILES: COc1cc(/C=C/C(O)=O)cc(OC)c1OC
• Target: Others
• Solubility: In Vitro: DMSO : 100 mg/mL (419.74 mM)

Bioactivity

• In Vivo:
  (E)-3, 4, 5-Trimethoxycinnamic acid (0-20 mg/kg, IP, once) shows anti-seizure effects. (E)-3, 4, 5-Trimethoxycinnamic acid (0-10 mg/kg, Orally, once) enhances hypnotic effects in pentobarbital-treated mice. Animal model: Ault male KunMing-strain mice (18-20 g, maximal electroshock (MES) and pentylenetetrazol (PTZ) models). Dosage: 5, 10 and 20 mg/kg; 10 mL/kg. Administration: IP, once. Result: Significantly decreased the incidence of MES-induced THE (tonic hindlimb extension) to 50% and 20% of the value of the vehicle controls at 10 and 20 mg/kg. Decreased the incidence of MES-induced THE to only 80% at 5 mg/kg. Significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. The incidence of generalized clonic convulsions (stage 4) disappeared at doses of both 10 and 20 mg/kg. Animal model: ICR male mice (25-28 g, 10-12 in each group). Dosage: 2, 5 and 10 mg/kg. Administration: Orally (p.o.), once, 15 min and 1 h prior to pentobarbital injection. Result: Significantly decreased locomotor activity at 10 mg/kg. Increased NREM and total sleep, but decreased wakefulness.
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• In Vitro:
  (E)-3, 4, 5-Trimethoxycinnamic acid (10 μg/mL, 1 h) increases the expressions of GAD65 and γ-subunit of GABAA receptors in the cerebellar granule cells. (E)-3, 4, 5-Trimethoxycinnamic acid (0-10 μg/mL, 1 h) shows a significant increase in Cl- influx. Western blot analysis. Cell line: Primary cultured cerebellar granule cells. Concentration: 10 μg/mL. Incubation time: 1 h. Result: Increased expression of GAD65 (glutamic acid decarboxylase) and γ-subunit of GABAA receptors, but did not influence the amounts of a-, b-subunits in the GABAA receptors. Cell Viability Assay Cell line: Primary cultured cerebellar granule cells. Concentration: 1, 3, 5, 10 μg/mL. Incubation time: 1 h. Result: Produced a significant increase in Cl- influx.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

O-Methylsinapic acid | 3,4,5-Trimethoxyphenylacrylic acid

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Others