3'-Sialyllactose sodium

SKU: orb1694383

Description

3'-Sialyllactose sodium is a prebiotic with demonstrated anti-inflammatory and immunomodulatory properties. It is applied in research on gut-brain axis interactions, inflammation, and autoimmune models, where it has been shown to mitigate anxiety-like behaviors and arthritic symptoms in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 128596-80-5
• MW: 655.53
• Purity: >99.99% (May vary between batches)
• Formula: C₂₃H₃₈NNaO₁₉
• SMILES: [Na+].[H][C@@](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@]2(C[C@H](O)[C@@H](NC(C)=O)[C@@]([H])(O2)[C@H](O)[C@H](O)CO)C([O-])=O)[C@H]1O)([C@H](O)CO)[C@H](O)[C@@H](O)C=O
• Target: NF-κB
• Solubility: DMSO:5 mg/mL (7.63 mM);H2O:100 mg/mL (152.55 mM);PBS (pH 7.2):10 mg/mL (15.25 mM)

Bioactivity

• In Vivo:
  For 6 weeks, mice were orally administered 3'-Sialyllactose sodium at doses of 10-100 mg/kg three times a week, protecting them against cartilage destruction from osteoarthritis.A single oral administration of 3'-Sialyllactose sodium at doses of 500, 1000, and 2000 mg/kg induces no micronuclei in the bone marrow cells of mice.In male and female beagle dogs, the maximum tolerance dose (MTD) of 3'-Sialyllactose sodium, given orally at doses ranging from 500 to 1000 to 2000 mg/kg at 4-day intervals, is greater than 2000 mg/kg.3'-Sialyllactose sodium demonstrates a lethal dose (LD50) above 20 g/kg bw, which is the highest tested dose.
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• In Vitro:
  For 24-36 hours at concentrations ranging from 0 to 250 μM, 3'-Sialyllactose sodium promotes and restores Col2a1 synthesis, accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines.In chondrocytes, 3'-Sialyllactose sodium (0-250 μM; 24 hours) activates the expression of Sox9 and inhibits NF-κB activation.In the presence or absence of metabolic activation, 3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect and does not exhibit evident growth inhibition and deposition in all strains.At a concentration of 1250 μg/mL, 3'-Sialyllactose sodium induces no chromosomal aberrations and demonstrates a non-clastogenic effect in either the presence or absence of metabolic activation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NF-κB, NFκB, NFkB, NF-kB, 3' Sialyllactose (sodium salt), 3'-Sialyllactose, 3'Sialyllactose (sodium salt), 3'-SL sodium

Compound Identifiers

PubChem CID

71308479