MTIC

SKU: orb1694400

Description

MTIC is the bioactive metabolite of the chemotherapeutic agent Temozolomide, utilized in oncology research for studying cancers like melanoma. 3'-Sialyllactose sodium salt is a prebiotic oligosaccharide investigated for its anti-inflammatory properties in gut health and immunology studies, applicable in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 3413-72-7
• MW: 168.16
• Purity: 99.61% (May vary between batches)
• Formula: C₅H₈N₆O
• SMILES: CN\N=N\c1[nH]cnc1C(N)=O
• Target: Drug Metabolite
• Solubility: Methanol:Slightly soluble;DMSO:20 mg/mL (118.93 mM)

Bioactivity

• In Vivo:
  MTIC was quantified in plasma of cancer patients (n=12) within 0.25-12 h after oral administration of temozolomide at 150 mg/m2. The mean maximum plasma concentration (Cmax) was 211 ng/ml which was observed at a mean Tmax of 1.88 h post dose. MTIC disappeared rapidly from plasma with an apparent in vivo half-life (t1/2) of 1.9 h similar to that of temozolomide.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Drug Metabolite, DrugMetabolite, NSC 407347, NSC407347, NSC-407347

Compound Identifiers

PubChem CID

76953