3-chloro-5-hydroxybenzoic Acid

SKU: orb1299782

Description

3-Chloro-5-hydroxybenzoic acid is a small molecule agonist for the GPR81 receptor, exhibiting an EC50 of 16 µM. This compound is a valuable research tool for studying the lactate-sensing receptor's role in metabolic regulation, neurobiology, and immunology in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 53984-36-4
• MW: 172.57
• Purity: 98.00% (May vary between batches)
• Formula: C₇H₅ClO₃
• SMILES: OC(=O)C1=CC(Cl)=CC(O)=C1
• Target: GPCR,Others,HCAR
• Solubility: DMSO:34 mg/mL (197.02 mM)

Bioactivity

• In Vivo:
  3-chloro-5-hydroxybenzoic Acid is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GPR81, lactate receptor, inhibit, Inhibitor, nonesterified free fatty acid, obesity, cholesterol, 3chloro5hydroxybenzoic Acid, 3-chloro-5-hydroxybenzoic Acid, 3 chloro 5 hydroxybenzoic Acid

Compound Identifiers

PubChem CID

13071646