3-chloro-5-hydroxybenzoic Acid

SKU: orb1220385

Description

3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM).

Key Properties

• CAS Number: 53984-36-4
• MW: 172.57
• Purity: >98% (HPLC)
• Formula: C₇H₅ClO₃
• SMILES: O=C(O)c1cc(O)cc(Cl)c1
• Target: GPR
• Solubility: DMSO:34mg/mL(197.03mM)

Bioactivity

• In Vivo:
  3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg. Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice. Animal model: C57Bl6/J mice (DIO mice). Dosage: 30, 100, and 300 mg/kg. Administration: PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks. Result: Significant reductions in nonesterified free fatty acid cholesterol (NEFAc) at all doses tested.
• In Vitro:
  3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50 = 16 μM), monkey (EC50 = 17 μM), dog (EC50 = 67 μM), rat (EC50 = 7 μM), mouse (EC50 = 22 μM), and hamster GPR81 (EC50 = 27 μM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GPR