2OH-BNPP1

SKU: orb1308726

Description

2OH-BNPP1 is a selective BUB1 kinase inhibitor used in cancer research. It serves as a chemical probe to study mitotic checkpoint signaling and has been utilized in both in vitro and in vivo models to investigate therapeutic strategies targeting cell division.

Key Properties

• CAS Number: 833481-73-5
• MW: 297.36
• Purity: 99.71% (May vary between batches)
• Formula: C₁₆H₁₉N₅O
• SMILES: CC(C)(C)n1nc(Cc2ccccc2O)c2c(N)ncnc12
• Target: Others
• Solubility: DMSO:≥ 100 mg/mL (336.30 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (11.1 mM)

Bioactivity

• In Vivo:
  2OH-BNPP1 (50 mg/kg) inhibits TGFβ signaling in vivo and significantly reduces phosphorylated SMAD2 levels in tumor-bearing mice.
• In Vitro:
  2OH-BNPP1 disrupts TGFβ signaling by hindering the phosphorylation of key proteins involved in both the canonical and non-canonical TGFβ pathways across a variety of cancerous and normal cell lines in a dose-dependent manner. At concentrations ranging from 0.1 to 50 μM, it effectively suppresses TGFβ signaling in a dose-dependent fashion.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, BUB1 kinase, 2OH BNPP1, 2OHBNPP1, 2OH-BNPP1, 2OH-BNPP-1

Compound Identifiers

PubChem CID

59796535