2OH-BNPP1

SKU: orb1217614

Description

2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.

Key Properties

• CAS Number: 833481-73-5
• MW: 297.35
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₉N₅O
• SMILES: CC(C)(C)n1nc(Cc(cccc2)c2O)c2c(N)ncnc12
• Target: BUB1 kinase
• Solubility: DMSO: 100 mg/mL (336.30 mM)

Bioactivity

• In Vivo:
  2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling In vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice.
• In Vitro:
  2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BUB1 kinase