2',5'-Dideoxyadenosine

SKU: orb1310068

Description

2',5'-Dideoxyadenosine is a potent, non-competitive inhibitor of adenylyl cyclase, binding to its P-site with an IC50 of 3 µM. This small molecule is a valuable research tool for studying cAMP-mediated signaling pathways in both cellular and biochemical assays, aiding investigations into cardiovascular and metabolic disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6698-26-6
• MW: 235.24
• Purity: 99.55%
• Formula: C₁₀H₁₃N₅O₂
• SMILES: C[C@H]1O[C@H](C[C@@H]1O)n1cnc2c(N)ncnc12
• Target: Adenylyl Cyclase,AChR,Adrenergic Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.25 mM);DMSO:2.36 mg/mL (10.03 mM)

Bioactivity

• Target IC50:
  Adenylyl cyclase:3 µM
• In Vivo:
  2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) completely inhibits the natriuretic, diuretic, and K+ and Cl- sparing effects of Fr-EtOAc in rats .
• In Vitro:
  2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively . 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 .
• Cell Research:
  Primary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min
• Animal Research:
  Male Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, heart, inhibit, nucleoside, Beta Receptor, cyclase, AdrenergicReceptor, Adenylyl cyclase (AC), Adenylylcyclase, Adenylyl cyclase, adenylyl, Adenylate Cyclase, Adrenergic Receptor, 2',5'Dideoxyadenosine, 2',5'-Dideoxyadenosine, 2',5' Dideoxyadenosine, analog, antiadrenergic, P-site

Compound Identifiers

PubChem CID

65166