2-Iodomelatonin

SKU: orb2901849

Description

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Key Properties

• CAS Number: 93515-00-5
• MW: 358.17
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₅IN₂O₂
• SMILES: COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1
• Target: Melatonin Receptor
• Solubility: In Vitro: DMF : 30 mg/mL (83.76 mM) DMSO: 30 mg/mL (83.76 mM)Ethanol : 20 mg/mL (55.84 mM)

Bioactivity

• In Vitro:
  2-iodomelatonin (0-7.5 μM; 18 hours) sharesthe protective properties of melatonin, it inhibits cell death of mutant htt ST14A and inhibits the increase in Rip2 expression in stressed mutant htt ST14A cells. Cell Viability Assay Cell line: Mutant htt ST14A cell. Concentration: 0 μM; 1 μM; 5 μM; 7.5 μM Incubation time: 18 hours. Result: Inhibited mutant htt ST14A cell death.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Melatonin Receptor