2-Iodomelatonin

SKU: orb1710608

Description

2-Iodomelatonin is a high-affinity, MT1-selective melatonin receptor agonist (Ki = 28 pM; 5-fold MT1/MT2 selectivity). It is extensively used as a radioligand in both in vitro and in vivo studies to map and characterize melatonin binding sites within central and peripheral nervous systems.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 93515-00-5
• MW: 358.17
• Purity: 99.70%
• Formula: C₁₃H₁₅IN₂O₂
• SMILES: COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1
• Target: Melatonin Receptor
• Solubility: DMSO:55 mg/mL (153.56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.58 mM)

Bioactivity

• In Vitro:
  2-iodomelatonin (0-7.5 μM; 18 hours) shares the protective properties of melatonin, inhibiting cell death and the increase in Rip2 expression in stressed mutant htt ST14A cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2 Iodomelatonin, 2Iodomelatonin, 2-Iodomelatonin, Melatonin Receptor, MelatoninReceptor

Compound Identifiers

PubChem CID

115348