2-HBA

SKU: orb1299874

Description

2-HBA is a synthetic curcumin analog that activates the Keap1-Nrf2-ARE signaling pathway, leading to the upregulation of detoxifying enzymes. This inducer is a valuable research tool for studying oxidative stress response and cytoprotection in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 131359-24-5
• MW: 266.29
• Purity: 99.76% (May vary between batches)
• Formula: C₁₇H₁₄O₃
• SMILES: Oc1ccccc1\C=C\C(=O)\C=C\c1ccccc1O
• Target: Reductase,Caspase,NADPH
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.02 mM);DMSO:100 mg/mL (375.53 mM)

Bioactivity

• In Vitro:
  2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, NQO1, 2 HBA, 2HBA, 2-HBA, Caspase

Compound Identifiers

PubChem CID

5472867