2-HBA

SKU: orb1220371

Description

2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.

Key Properties

• CAS Number: 131359-24-5
• MW: 266.29
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₄O₃
• SMILES: O=C(/C=C/c1ccccc1O)/C=C/c1ccccc1O
• Target: NADPH
• Solubility: DMSO:100 mg/mL (375.53 mM)

Bioactivity

• In Vitro:
  When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NADPH