2-Fluoroadenine

SKU: orb1940560

Description

2-Fluoroadenine has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.(In Vitro):In Balb-3T3 cells, 2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses. In CEM cells, 2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. In nonproliferating MRC-5 cells, 2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity.

Key Properties

• CAS Number: 700-49-2
• MW: 153.12
• Purity: >98% (HPLC)
• Formula: C₅H₄FN₅
• SMILES: Nc1[nH]c(F)nc2ncnc12
• Target: DNA/RNA Synthesis
• Solubility: In Vitro: DMSO : 20.83 mg/mL (136.04 mM)

Bioactivity

• In Vitro:
  2-Fluoroadenine (2 μM; 4 hours) inhibits CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis.2-Fluoroadenine (0-1000 μM; 96 hours) exhibits cytotoxicity in nonproliferating MRC-5 cells.2-Fluoroadenine (0.22, 2.2 and 22 μM; 30 hours) inhibits protein, RNA, and DNA syntheses in Balb-3T3 cells incubated in serum-free medium. Cell Proliferation Assay Cell line: CEM cells. Concentration: 2 μM. Incubation time: 4 hours. Result: Inhibited CEM cell growth by targeting one or more enzymes involved in either RNA or protein synthesis. Cell Cytotoxicity Assay Cell line: MRC-5 cells. Concentration: 0-1000 μM. Incubation time: 4 hours. Result: Exhibited cytotoxicity in nonproliferating MRC-5 cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 27364 | 2- Fluoro-6-Aminopurine

Quick Database Links

Gene Symbol

DNA/RNA Synthesis