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2'-Fluoro-2'-Deoxyadenosine

SKU: orb1940157

Description

2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.

Images & Validation

Key Properties

CAS Number64183-27-3
MW269.236
Purity>98% (HPLC)
FormulaC10H12FN5O3
SMILESNc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F
TargetNucleoside Antimetabolite/Analog
SolubilityIn Vitro: DMSO : 50 mg/mL (185.71 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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