2'-Deoxy-2'-fluorocytidine

SKU: orb1940296

Description

2'-Deoxy-2'-fluorocytidine is an nucleoside analog and inhibits of Crimean-Congo hemorrhagic fever virus (CCHFV) replication potently.(In Vitro):2'-Deoxy-2'-fluorocytidine (EC50 = 61 ± 18 nM) has 200 × the potency of ribavirin (EC50 = 12.5 ± 2.6 μM), as well as 17 × the potency of T-705 (favipiravir), another compound with reported anti-CCHFV activity (EC50 = 1.03 ± 0.16 μM). 2'-Deoxy-2'-fluorocytidine acts synergistically with T-705 to inhibit CCHFV replication without causing cytotoxicity.

Key Properties

• CAS Number: 10212-20-1
• MW: 245.21
• Purity: >98% (HPLC)
• Formula: C₉H₁₂FN₃O₄
• SMILES: Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2F)c(=O)n1
• Target: Nucleoside Antimetabolite/Analog
• Solubility: In Vitro: H2O : 5 mg/mL (20.39 mM)

Bioactivity

• In Vitro:
  2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Nucleoside Antimetabolite/Analog