2'-Deoxy-2'-fluorocytidine

SKU: orb1303699

Description

2'-Deoxy-2'-fluorocytidine is a nucleoside analog that acts as a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. It is a valuable research tool for studying CCHFV antiviral mechanisms in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 10212-20-1
• MW: 245.21
• Purity: 99.90% (May vary between batches)
• Formula: C₉H₁₂FN₃O₄
• SMILES: Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2F)c(=O)n1
• Target: Influenza Virus,Nucleoside Antimetabolite/Analog
• Solubility: DMSO:50 mg/mL (203.91 mM);H2O:5 mg/mL (20.39 mM)

Bioactivity

• Target IC50:
  CCFHV:61 ± 18 nM(EC50)
• In Vitro:
  2'-Deoxy-2'-fluorocytidine exhibits antiviral activity with 50% effective concentrations (EC50) of 61 nM against CCHFV and 31 nM against CCHFV/ZsG in Huh7 cells and shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Crimean-Congo hemorrhagic fever, Crimean-Congo hemorrhagic fever virus (CCHFV), Analog, Antiviral,CCHFV, 2' Deoxy 2' fluorocytidine, 2'-Deoxy-2'-fluorocytidine, 2'Deoxy2'fluorocytidine, Inhibitor, InfluenzaVirus, Influenza Virus, inhibit, nucleoside analog, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite

Compound Identifiers

PubChem CID

101507