2'-Deoxy-2'-fluorocytidine

SKU: orb1303699

Description

2'-Deoxy-2'-fluorocytidine is a nucleoside analog that acts as a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. It is a valuable research tool for studying CCHFV antiviral mechanisms in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 10212-20-1
• MW: 245.208
• Purity: 99.90% (May vary between batches)
• Formula: C₉H₁₂FN₃O₄
• SMILES: OC[C@@H]1[C@H]([C@@H](F)[C@H](N2C(N=C(C=C2)N)=O)O1)O
• Target: Nucleoside Antimetabolite/Analog,Influenza Virus
• Solubility: DMSO:50 mg/mL (203.91 mM);H2O:5 mg/mL (20.39 mM)

Bioactivity

• Target IC50:
  CCFHV:61 ± 18 nM(EC50)
• In Vitro:
  2'-Deoxy-2'-fluorocytidine exhibits antiviral activity with 50% effective concentrations (EC50) of 61 nM against CCHFV and 31 nM against CCHFV/ZsG in Huh7 cells and shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Crimean-Congo hemorrhagic fever, Crimean-Congo hemorrhagic fever virus (CCHFV), Analog, Antiviral,CCHFV, 2' Deoxy 2' fluorocytidine, 2'-Deoxy-2'-fluorocytidine, 2'Deoxy2'fluorocytidine, Inhibitor, InfluenzaVirus, Influenza Virus, inhibit, nucleoside analog, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite

Compound Identifiers

PubChem CID

101507