17α-Hydroxyprogesterone

SKU: orb1308651

Description

17α-Hydroxyprogesterone (17-OHP) is a key steroid hormone intermediate in glucocorticoid synthesis and a physiological progestin. It acts by binding to and activating cytoplasmic progesterone receptors, modulating gene expression. This compound is widely used in research on steroidogenesis, reproductive endocrinology, and hormone receptor signaling in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 68-96-2
• MW: 330.46
• Purity: 99.89% (May vary between batches)
• Formula: C₂₁H₃₀O₃
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@@]2(C(C)=O)O)[H]
• Target: Endogenous Metabolite,Progesterone Receptor,Estrogen/progestogen Receptor
• Solubility: DMSO:40.08 mg/mL (121.29 mM);Ethanol:61 mg/mL (184.59 mM)

Bioactivity

• In Vivo:
  17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germinal vesicle breakdown).
• In Vitro:
  17α-Hydroxyprogesterone is an agonist of the progesterone receptor (PR) similarly to progesterone, albeit weakly in comparison. It is a chemical intermediate in the biosynthesis of steroid hormones, including the androgen and estrogen sex hormones and the glucocorticoids and mineralocorticoids.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, 17a-Hydroxyprogesterone, 17alpha-Hydroxyprogesterone, 17αHydroxyprogesterone, 17α-Hydroxyprogesterone, 17α Hydroxyprogesterone, 17-Hydroxyprogesterone, 17-OHP, inhibit, NR3C3, Hydroxyprogesterone, EstrogenReceptor, Estrogen Receptor, ER, Endogenous Metabolite, Inhibitor, ProgesteroneReceptor, Progesterone Receptor, progestogenReceptor, progestogen Receptor

Compound Identifiers

PubChem CID

6238