1,5-Isoquinolinediol

SKU: orb1300119

Description

1,5-Isoquinolinediol is a potent PARP1 inhibitor (IC50: 0.39 µM) used to investigate DNA repair mechanisms and oxidant-induced apoptosis. This tool compound is applicable for both in vitro cellular studies and in vivo animal models of stress and disease.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 5154-02-9
• MW: 161.16
• Purity: 99.43% (May vary between batches)
• Formula: C₉H₇NO₂
• SMILES: Oc1cccc2c(O)nccc12
• Target: PARP
• Solubility: Ethanol:20 mg/mL (124.1 mM);H2O:1 mg/mL (6.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.41 mM);DMSO:55 mg/mL (341.28 mM)

Bioactivity

• Target IC50:
  PARP1:0.39 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

diabetic, 1,5 Isoquinolinediol, 1,5Isoquinolinediol, 1,5-Isoquinolinediol, 1188540, inhibit, PARP, PARP1, NADPH, Inhibitor, retinopathy, stress, poly ADP ribose polymerase, oxidase, oxidative

Compound Identifiers

PubChem CID

1340