1,5-Isoquinolinediol

SKU: orb1222952

Description

1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

Key Properties

• CAS Number: 5154-02-9
• MW: 161.16
• Purity: >98% (HPLC)
• Formula: C₉H₇NO₂
• SMILES: Oc1cccc2c1cc[nH]c2=O
• Target: PARP1
• Solubility: In Vitro: DMSO : 37.04 mg/mL (229.83 mM)

Bioactivity

• In Vitro:
  1, 5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene.1, 5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1, 5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1, 5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1, 5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP1