1,4-Chrysenequinone

SKU: orb1310086

Description

1,4-Chrysenequinone is a potent and selective aryl hydrocarbon receptor (AhR) agonist. This small molecule is used in research to study AhR signaling pathways in both cellular and animal models, facilitating investigations into toxicology, immunology, and carcinogenesis.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 100900-16-1
• MW: 258.27
• Purity: 99.84%
• Formula: C₁₈H₁₀O₂
• SMILES: O=C1C=CC(=O)c2c1ccc1c2ccc2ccccc12
• Target: AhR,Aryl Hydrocarbon Receptor
• Solubility: DMSO:3.33 mg/mL (12.89 mM)

Bioactivity

• Target IC50:
  AhR:1.9 μM(mouse hepatoma cell systems)|AhR:9.7 nM(yeast)
• In Vitro:
  1,4-Chrysenequinone shows AhR ligand activity, with ECTCDD25s (concentration equivalent with 25% of TCDD max) of 9.7 nM and 1.9 μM in yeast and mouse hepatoma cell systems, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Chrysene-1,4-dione, Aryl Hydrocarbon Receptor, 1,4 Chrysenequinone, 1,4-Chrysenequinone, 1,4Chrysenequinone, AhR

Compound Identifiers

PubChem CID

180933