1,2-Bis(2-iodoethoxy)ethane

SKU: orb1940682

Description

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 and SJF620. MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively.(In Vitro):1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 and SJF620. PROTAC MT802 has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane.

Key Properties

• CAS Number: 36839-55-1
• MW: 369.969
• Purity: >98% (HPLC)
• Formula: C₆H₁₂I₂O₂
• SMILES: ICCOCCOCCI

Bioactivity

• In Vitro:
  1, 2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1, 2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802(HY-122562) has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1, 2-Bis(2-iodoethoxy)ethane.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only