1,2-Bis(2-iodoethoxy)ethane

SKU: orb1307586

Description

1,2-Bis(2-iodoethoxy)ethane is a polyethylene glycol (PEG)-based linker used in constructing PROTAC molecules. It serves as a key component in the synthesis of potent BTK degraders like MT-802 and SJF620, which demonstrate low nanomolar degradation potency in cellular studies. This linker is applied in chemical biology and drug discovery research for developing targeted protein degradation tools.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 36839-55-1
• MW: 369.97
• Purity: ≥98% (May vary between batches)
• Formula: C₆H₁₂I₂O₂
• SMILES: ICCOCCOCCI
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  1,2-Bis(2-iodoethoxy)ethane, a PROTAC linker of the polyethylene glycol (PEG) class, is essential for synthesizing various PROTACs like MT802 and SJF620. Notably, PROTAC MT802 includes a ligand targeting BTK and another targeting the E3 ligase cereblon (CRBN), both bridged by the PEG linker 1,2-Bis(2-iodoethoxy)ethane.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1,2Bis(2iodoethoxy)ethane, 1,2-Bis(2-iodoethoxy)ethane, 1,2 Bis(2 iodoethoxy)ethane, inhibit, Inhibitor, PEGs, PROTAC Linkers, PROTACLinker, PROTAC Linker

Compound Identifiers

PubChem CID

593436