ZYN57939

SKU: orb1298410

Description

ZYN57939 (MTR-106) is a selective RNA polymerase I inhibitor used in cancer research. It demonstrates potent in vitro activity, such as an IC50 of 0.855 µM against HT-29 human colon cancer cells, and is investigated for its role in targeting dysregulated ribosomal biogenesis in oncology studies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 1639357-93-9
• MW: 525.62
• Purity: 99.81%
• Formula: C₂₈H₂₇N₇O₂S
• SMILES: C(NCC=1C=NC(C)=CN1)(=O)C2=C3N(C=4C(C2=O)=CC=C(N4)N5C[C@@]6([C@](C5)(CN(C)C6)[H])[H])C=7C(S3)=CC=CC7
• Target: Apoptosis,DNA/RNA Synthesis
• Solubility: H2O:Insoluble;DMSO:5.26 mg/mL (10.01 mM)

Bioactivity

• In Vivo:
  ZYN57939 oral and i.v. administration significantly impaired tumor growth in BRCA-deficient xenograft mouse models.However, ZYN57939 showed modest activity against talazoparib-resistant xenograft models.In rats, the drug rapidly distributes to tissues within 5 min, and its average concentrations were 12-fold higher in the tissues than in the plasma.Overall, ZYN57939 as a novel G-quadruplex stabilizer with high tissue distribution, and it may serve as a potential anticancer agent.
• In Vitro:
  MTR-106, stabilizes DNA G-quadruplexes in vitro. MTR-106 displayed significant antiproliferative activity in homologous recombination repair (HR)-deficient and PARP inhibitor (PARPi)-resistant cancer cells. Moreover, MTR-106 increased DNA damage and promoted cell cycle arrest and apoptosis to inhibit cell growth.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MTR 106, MTR106, MTR-106, DNA Synthesis, DNASynthesis, RNASynthesis, RNA Synthesis, RNA polymerase I, ZYN 57939, ZYN57939, ZYN-57939

Compound Identifiers

PubChem CID

165429166