Zymosan A

SKU: orb2893573

Description

Zymosan A, a TLR2 agonist from yeast cell walls, activates Wnt signaling to upregulate ASCL2 and promote intestinal stem cell regeneration, offering radioprotection against radiation-induced injury. It is also widely used to model immune responses, including peritonitis, in experimental research.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 58856-93-2
• Target: TLR
• Solubility: H2O:< 1 mg/mL (insoluble);DMSO:1 mg/mL

Bioactivity

• In Vivo:
  Methods: Zymosan A (25.0 mg/Kg, intraperitoneal injection, 24 and 2 hours before IR) was given to mice to observe its effect on IR-induced intestinal damage in mice. Results: The radioprotective effect of Zymosan A was even better when it was given 24 and 2 hours before IR. Zymosan A had a significant radioprotective effect on irradiated mice, and Zymosan A alleviated IR-induced intestinal damage in mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Zymosan A, Zymosan A from Saccharomyces cerevisia, Zymosan A from Saccharomyces cerevisiae

Quick Database Links

Gene Symbol

TLR