ZX703

SKU: orb2695184

Description

ZX703 is a PROTAC molecule that induces GPX4 degradation via dual ubiquitin-proteasome and autophagy-lysosome pathways (DC50 = 0.315 µM). This degradation triggers lipid ROS accumulation and ferroptosis, providing a research tool for studying this cell death mechanism in cancer models both in vitro and in vivo.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• MW: 1039.68
• Purity: 99.72% (May vary between batches)
• Formula: C₅₄H₆₇ClN₈O₉S
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCOC4=CC=C(C=C4)C(C5=CC=C(C=C5)Cl)N6CCN(CC6)C(=O)C7=NOC(=C7[N+](=O)[O-])C)O
• Target: GPX,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

89278903