ZX703

SKU: orb2695184

Description

ZX703 is a PROTAC molecule that induces GPX4 degradation via dual ubiquitin-proteasome and autophagy-lysosome pathways (DC50 = 0.315 µM). This degradation triggers lipid ROS accumulation and ferroptosis, providing a research tool for studying this cell death mechanism in cancer models both in vitro and in vivo.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• MW: 654.1
• Formula: C₄₁H₈₃NO₄
• SMILES: [C@H]([C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)(NC(CCCCCCCCCCCCCCCCCCCCCC)=O)CO
• Target: GPX,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

89278903