ZW-49

SKU: orb3211223

Description

ZW-49 is a pan-EGFR inhibitor with oral bioavailability, showing IC50 values ranging from 0.03 to 1.5 nM. It effectively inhibits all EGFR mutant subtypes and demonstrates selectivity for wild-type EGFR and other target families. ZW-49 blocks the ATP binding site and occupies a conserved hydrophobic sub-pocket, preventing steric clashes with P-loop mutations (PACC). It suppresses cancer cell proliferation, induces G0/G1 cell cycle arrest and apoptosis, and exhibits antiproliferative activity in xenograft mouse models. ZW-49 is applicable in cancer research, including studies on non-small cell lung cancer.

Key Properties

• CAS Number: 2055109-19-6
• MW: 588.66
• Formula: C₃₃H₃₂N₈O₃
• SMILES: O=C(C=C)NC1=CC=CC(=C1)N2C(=O)C(=NC3=CN=C(N=C32)NC4=CC=C(C=C4OC)N5CCN(C)CC5)C=6C=CC=CC6
• Target: Apoptosis,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,EGFR