ZT-12-037-01

SKU: orb1301658

Description

Zt-12-037-01 is a potent and ATP-competitive inhibitor of STK19, demonstrating IC50 values of 23.96 nM against the wild-type and 27.94 nM against the D89N mutant. This small molecule is a valuable research tool for investigating STK19 kinase function in biochemical and cellular assays relevant to cancer and dermatological research.

Research Area

Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 2328073-61-4
• MW: 385.5
• Purity: 98.00% (May vary between batches)
• Formula: C₂₁H₃₁N₅O₂
• SMILES: COc1cc2nc(NC3CC3)nc(NC3CCN(CC3)C(C)C)c2cc1OC
• Target: Serine Protease,Ras
• Solubility: DMSO:41 mg/mL (106.36 mM)

Bioactivity

• Target IC50:
  STK19 (WT):23.96 nM |STK19 (D89N):27.94 nM
• In Vivo:
  ZT-12-037-01 as a specific STK19-targeted inhibitor and it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vivo.
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• In Vitro:
  ZT-12-037-01 significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation and proliferation.
• Animal Research:
  ZT-12-037-01 (injection subcutaneously; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Ras, Serine Protease, SerineProtease, STK19, ZT 12 037 01, ZT1203701, ZT-12-037-01

Compound Identifiers

PubChem CID

138911316