ZQ-16

SKU: orb1693570

Description

ZQ-16 is a potent and selective GPR84 agonist (EC50 = 0.213 µM) that activates diverse signaling pathways, including calcium flux, ERK1/2 phosphorylation, and β-arrestin recruitment. This tool compound is valuable for investigating GPR84's role in inflammation and immunity in both cellular and animal models, supporting basic research and drug discovery efforts.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 376616-73-8
• MW: 228.31
• Purity: 98.52%
• Formula: C₁₀H₁₆N₂O₂S
• SMILES: O=C1C=C(O)N=C(SCCCCCC)N1
• Target: GPCR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.76 mM);DMSO:20 mg/mL (87.6 mM)

Bioactivity

• In Vitro:
  Treatment of HEK293 cells expressing GPR84 with ZQ-16 (10 μM, 5 minutes) induces phosphorylation of ERK1/2 in the cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZQ 16, ZQ16, ZQ-16

Compound Identifiers

PubChem CID

1912564