ZNL 02-096

SKU: orb1690088

Description

ZNL 02-096 (Pomalidomide-C3-adavosertib) is a potent and selective Wee1 degrader (IC50=3.58 nM) that spares PLK1. It induces Wee1 degradation, DNA damage, G2/M arrest, and apoptosis in MOLT-4 cells in vitro and demonstrates broad anti-proliferative activity across cancer cell lines, supporting its use in oncology and DNA damage response research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2414418-49-6
• MW: 799.88
• Purity: 99.84%
• Formula: C₄₂H₄₅N₁₁O₆
• SMILES: C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(CCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)CC4)N2)C=8N=C(C(C)(C)O)C=CC8
• Target: Apoptosis,PROTACs,Wee1
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.25 mM);DMSO:50 mg/mL (62.51 mM)

Bioactivity

• In Vitro:
  ZNL 02-096 (1 nM-10 μM; 24, 48, and 72 h; OVCAR8, COV362, and Kuramochi cells) induces CRBN-dependent anti-proliferative effects and synergizes with Olaparib. ZNL 02-096 (6 h) degrades Wee1 in OVCAR8 cells, with maximal degradation observed at a 100 nM treatment. ZNL 02-096 (100 nM; 24 h) induces DNA damage, apoptosis, and deregulation of the G2/M checkpoint.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Wee1, Pomalidomide-C3-adavosertib, ZNL 02-096

Compound Identifiers

PubChem CID

153555373