ZMC1

SKU: orb1305450

Description

NSC319726

Research Area

Cell Biology

Key Properties

• CAS Number: 71555-25-4
• MW: 234.32
• Purity: 97.48%
• Formula: C₁₁H₁₄N₄S
• SMILES: C\C(=N/NC(=S)N1CCC1)c1ccccn1
• Target: MDM-2/p53,p53
• Solubility: DMSO:23.4 mg/mL (99.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.54 mM);Ethanol:2.3 mg/mL (9.82 mM)

Bioactivity

• Target IC50:
  p53 (R175):8 nM
• In Vivo:
  In cells with mutant p53, NSC319726 IC50 8 nM) causes a WT-like conformational change in the mutant protein that repairs sequence-specific p53 transcription.
• In Vitro:
  In cells with mutant p53, NSC319726 IC50 8 nM) causes a WT-like conformational change in the mutant protein that repairs sequence-specific p53 transcription.
• Cell Research:
  Viability assays are done the cells ( × 04 cells/well, in 1 mL culture) are cultured in a 12-well plate to reac the 50%–60% confluence o the second day when treated with serial dilutions o the compound the growth is measured by Guava ViaCount reagent and Guava PCA instrument after incubation for 3 days.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZMC 1, ZMC-1, inhibit, NSC 319726, p53 (R175), NSC319726, NSC-319726, MDM-2/p53, Inhibitor

Compound Identifiers

PubChem CID

5351307