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ZM484

SKU: orb3173692

Description

ZM484 is a potent dual inhibitor of p53-MDM2/TOP1, demonstrating antiproliferative and antitumor activities both in vivo and in vitro. By releasing CPT and an effective p53-MDM2 inhibitor, ZM484 efficiently upregulates p53 and MDM2 proteins while maintaining TOP1 inhibitory activity. It induces cell cycle arrest and apoptosis by modulating the expression of key apoptosis and cell cycle-related proteins (including caspase-3, Bcl-2, and Cyclin B1). ZM484 is applicable for colorectal cancer research.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Protein Biochemistry

Images & Validation

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ZM484

Key Properties

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TargetCaspase,Topoisomerase,Serine/threonin kinase,MDM-2/p53,Bcl-2 Family

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol
Caspase,Topoisomerase,Serine/threonin kinase,MDM-2/p53,Bcl-2 Family

Protocol Information

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Email

[email protected]

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

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