ZM323881 hydrochloride

SKU: orb1705910

Description

ZM323881 hydrochloride is a potent and selective inhibitor of VEGFR2 (KDR). It is widely used in angiogenesis research to study tumor growth and metastasis in both cellular assays and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 193000-39-4
• MW: 411.86
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₁₉ClFN₃O₂
• SMILES: Cl.Cc1cc(F)c(Nc2ncnc3cc(OCc4ccccc4)ccc23)cc1O
• Target: FGFR,EGFR,VEGFR,PDGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.86 mM);DMSO:40 mg/mL (97.12 mM)

Bioactivity

• Target IC50:
  VEGFR2:<2 nM
• In Vivo:
  At concentrations below 1 μM, ZM323881 inhibits the proliferation of neural stem cells stimulated by VEGF in a dose-dependent manner. It impedes the activation of extracellular signal-regulated kinase, p38, Akt, and endothelial nitric oxide synthase (eNOS) through VEGF blockade at 1 μM, without suppressing the expression of the VEGFR-1 specific ligand, placental growth factor (PlGF), in human aortic endothelial cells (HAECs). Additionally, 1 μM ZM323881 disrupts VEGF-induced membrane extension, cell migration, and tube formation in HAECs and reverses the phosphorylation of CrkII and its SRC homology 2 domain-binding protein p130Cas, key in regulating endothelial cell migration. ZM323881 inhibits the proliferation of HUVEC cells induced by VEGF-A, EGF, and bFGF, with IC50 values of 8 nM, 1.9 μM, and 1.6 μM respectively. At 10 nM, ZM323881 eradicates the increase in vascular permeability mediated by VEGF-A in the mesenteric microvasculature of male leopards. Furthermore, 10 nM ZM323881 completely obstructs VEGF-induced promoter activity and Hif-1α protein accumulation in VEGF-stimulated SCC-9 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, FGFR1, EGFR, inhibit, ZM 323881 HCl, ZM 323881 Hydrochloride, ZM 323881 hydrochloride, ZM 323881, PDGFRβ, Vascular endothelial growth factor receptor, VEGFR2, VEGFR1, VEGFR, ZM323881, ZM-323881, ZM323881 hydrochloride, ZM323881 Hydrochloride, ZM-323881 Hydrochloride, ZM-323881 hydrochloride

Compound Identifiers

PubChem CID

22624897