ZM 306416

SKU: orb1224231

Description

ZM 306416 is a VEGFR (Flt and KDR) inhibitor for VEGFR1 with IC50 of 0.33 μM, but also found to inhibit EGFR with IC50 of <10 nM.

Key Properties

• CAS Number: 690206-97-4
• MW: 333.74
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₃ClFN₃O₂
• SMILES: COC1=CC2=NC=NC(NC3=CC=C(Cl)C=C3F)=C2C=C1OC
• Target: Bcr-Abl
• Solubility: DMSO: 67 mg/mL (200.75 mM)

Bioactivity

• In Vitro:
  ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50 = 0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CB-676475

Quick Database Links

Gene Symbol

Bcr-Abl