ZLN005

SKU: orb1307411

Description

ZLN005

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 49671-76-3
• MW: 250.34
• Purity: 98.59%
• Formula: C₁₇H₁₈N₂
• SMILES: CC(C)(C)c1ccc(cc1)-c1nc2ccccc2[nH]1
• Target: Autophagy
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:85 mg/mL (339.54 mM);Ethanol:2 mg/mL (7.99 mM)

Bioactivity

• In Vivo:
  In L6 myotubes, ZLN005 enhances glucose uptake and fatty acid oxidation by activating AMP-activated protein kinase (AMPK), and it elevates the expression of PGC-1α genes and downstream genes without significant toxicity. However, the same effects are not observed in primary rat hepatocytes, indicating cell-specific actions.
• In Vitro:
  ZLN005 (15 mg/kg, p.o.) exhibits anti-hyperglycemic and anti-hyperlipidemic effects, and enhances insulin sensitivity in db/db mice without effecting lean mice.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZLN005, ZLN-005, ZLN 005, PPARγ coactivator-1α, PGC-1α, Autophagy, inhibit, Inhibitor

Compound Identifiers

PubChem CID

899323